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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMGCS1
All Species:
35.45
Human Site:
Y236
Identified Species:
52
UniProt:
Q01581
Number Species:
15
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q01581
NP_001091742.1
520
57294
Y236
L
D
R
C
Y
S
V
Y
C
K
K
I
H
A
Q
Chimpanzee
Pan troglodytes
XP_517780
610
66491
Y326
L
D
R
C
Y
S
V
Y
C
K
K
I
R
A
Q
Rhesus Macaque
Macaca mulatta
XP_001090857
592
65050
Y308
L
D
R
C
Y
S
V
Y
C
K
K
I
R
A
Q
Dog
Lupus familis
XP_536483
637
69021
Y353
L
D
R
C
Y
S
V
Y
R
K
K
I
R
A
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q8JZK9
520
57550
Y236
L
D
R
C
Y
S
V
Y
R
K
K
I
R
A
Q
Rat
Rattus norvegicus
P17425
520
57415
Y236
L
D
R
C
Y
S
V
Y
R
K
K
I
R
A
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506375
520
57160
Y236
L
D
R
C
Y
S
V
Y
R
N
K
I
R
A
R
Chicken
Gallus gallus
P23228
522
57541
Y236
L
D
R
C
Y
S
V
Y
R
N
K
I
H
A
Q
Frog
Xenopus laevis
NP_001087380
520
57303
Y236
L
D
H
C
Y
S
T
Y
R
K
K
I
H
A
Q
Zebra Danio
Brachydanio rerio
NP_957379
508
55918
Y225
L
D
Q
C
Y
S
V
Y
K
N
K
I
H
A
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_524711
465
51158
E191
G
L
R
A
T
H
M
E
H
A
Y
D
F
Y
K
Honey Bee
Apis mellifera
XP_397202
453
50855
D179
P
N
A
P
L
I
I
D
R
G
V
R
S
S
C
Nematode Worm
Caenorhab. elegans
P54871
462
51397
R187
D
A
S
I
P
I
D
R
Q
F
S
A
C
H
M
Sea Urchin
Strong. purpuratus
XP_801879
508
56054
A229
S
I
Q
C
Y
L
G
A
L
D
K
C
Y
E
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P54873
461
51076
A187
K
L
R
A
S
H
M
A
H
V
Y
D
F
Y
K
Baker's Yeast
Sacchar. cerevisiae
P54839
491
54995
I217
W
I
G
P
D
A
P
I
V
F
D
S
V
R
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85
87.3
78.6
N.A.
94.6
94.8
N.A.
90.1
83.9
80
77.6
N.A.
58
54.6
38.4
63.2
Protein Similarity:
100
85
87.3
80.5
N.A.
97.5
97.6
N.A.
95.3
91
88.6
87.1
N.A.
69.6
68.6
54.8
75.3
P-Site Identity:
100
93.3
93.3
86.6
N.A.
86.6
86.6
N.A.
73.3
86.6
80
73.3
N.A.
6.6
0
0
20
P-Site Similarity:
100
93.3
93.3
86.6
N.A.
86.6
86.6
N.A.
80
86.6
80
86.6
N.A.
20
20
0
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
44
45.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
60.1
60.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
7
13
0
7
0
13
0
7
0
7
0
63
7
% A
% Cys:
0
0
0
69
0
0
0
0
19
0
0
7
7
0
7
% C
% Asp:
7
63
0
0
7
0
7
7
0
7
7
13
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
7
0
0
0
0
0
7
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
13
0
0
13
0
0
% F
% Gly:
7
0
7
0
0
0
7
0
0
7
0
0
0
0
0
% G
% His:
0
0
7
0
0
13
0
0
13
0
0
0
25
7
0
% H
% Ile:
0
13
0
7
0
13
7
7
0
0
0
63
0
0
0
% I
% Lys:
7
0
0
0
0
0
0
0
7
44
69
0
0
0
13
% K
% Leu:
63
13
0
0
7
7
0
0
7
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
13
0
0
0
0
0
0
0
7
% M
% Asn:
0
7
0
0
0
0
0
0
0
19
0
0
0
0
0
% N
% Pro:
7
0
0
13
7
0
7
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
13
0
0
0
0
0
7
0
0
0
0
0
50
% Q
% Arg:
0
0
63
0
0
0
0
7
44
0
0
7
38
7
19
% R
% Ser:
7
0
7
0
7
63
0
0
0
0
7
7
7
7
0
% S
% Thr:
0
0
0
0
7
0
7
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
57
0
7
7
7
0
7
0
0
% V
% Trp:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
69
0
0
63
0
0
13
0
7
13
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _